We’ve heard about the nutraceutical properties of Moringa Oleifera, but still little of its pharmacological properties. But where do these extraordinary properties come from?
The real protagonists are the secondary Metabolites!
Secondary metabolites are chemical compounds produced by plant metabolism. They are fundamental for the implementation of defense mechanisms against parasites and predators, for species competition and for facilitating reproductive processes. It is no coincidence that many of the drugs used by man have a secondary metabolite of plant origin as their active ingredient.
In fact, our mission is to preserve the precious secondary metabolites, through special leaf processing techniques.
But let's get to the point. What are the pharmacological properties that make Moringa a miraculous tree?
The leaf extract shows a significant cholesterol-lowering action, thanks to the presence of a bioactive phytocostentent, beta-sitosterol, which acts by inhibiting the intestinal absorption of dietary cholesterol, acting on the entero-hepatic mechanism. Studies show a reduction in serum levels of both LDL cholesterol and triglycerides without altering the blood profile of HDL cholesterol (known as good cholesterol), and a beneficial action also on the lipid profile of the liver and heart.
Moringa Oleifera is able to act significantly on glucose metabolism. Scientific studies show that, thanks to the presence of thiocarbamates that stimulate beta-pancreatic cells in secreting insulin, Moringa Oleifera is able to restore optimal blood glucose levels, improve insulin sensitivity and thereby reduce complications related to type 2 diabetes mellitus..
nflammation is a physiological response implemented by our body to protect us from the harmful effects of physical, chemical and biological agents, and to restore tissue lesions. Inflammatory cytokines such as IL-1β and TNF-α can stimulate the expression of enzymes (iNOS and COX-2), thus increasing the inflammatory process.
Several scientific studies have shown that the Moringa Oleifera performs a double action: by reducing the production of the molecules involved in inflammatory processes, and by inhibiting the expression of a gene (ReLA) responsible for regulating the immune response to infections, it is able to alleviate the symptomatology typical of an inflammatory process, from simple swelling and redness, to muscular, articular, rheumatic pains to headaches.
Antioxidant and hepatoprotective activity
Oxidative stress occurs when there are too many free radicals in the body that cause structural alterations in proteins, lipids and nucleic acids.
Several studies have shown how oxidative stress plays a fundamental role in the development of many diseases: cardiovascular diseases, liver and neurodegenerative diseases as well as inflammatory diseases, such as lupus and arthritis.
By causing structural alterations in the synthesis of collagen and elastin, free radicals also contribute to premature aging of the skin.
Our body is therefore continuously bombarded and to protect itself it has developed enzymatic systems that sometimes are not sufficient.
It is precisely here that Moringa Oleifera enters the field. With 157.600 ORAC points, it stands on the highest steps in the ranking of foods containing antioxidants.
Its leaves are particularly rich in polyphenols and flavonoids (quercetin, rutin) with a strong antioxidant and anti-inflammatory effect, used to counteract the cellular aging induced by radical species. Furthermore, Quercetin, as demonstrated in various scientific publications, has an important hepatoprotective action.
What makes Moringa Oleifera peculiar from this point of view, is above all the ability to effectively restore the levels of our body's enzymes (superoxide dismutase, glutathione peroxidase) involved in the protection from oxidative stress and to to prevent lipid peroxidation in the liver.
Diuretic antihypertensive activity
The analysis of the ethanol extract of leaves of the Moringa Oleifera has allowed to isolate 4 compounds (Niazinina A, B, AB, Niazimicina) that show a hypotensive effect behaving as calcium antagonists. Leaves, roots and seeds seem to have diuretic properties that play a complementary role in the overall effect of lowering blood pressure.
The leaf extract also shows a significant hypocholesterolemic action, thanks to the presence of a bioactive phyto-constituent, beta-sitosterol, which acts by inhibiting intestinal absorption of dietary cholesterol, acting on the entero-hepatic mechanism. The studies show a reduction in the serum levels of both LDL and triglycerides without altering the blood profile of HDL cholesterol (known as good cholesterol), and a beneficial effect on the lipid profile of the liver and heart.
Acting on several fronts, the Moringa Oleifera, represents a strong ally for our health!
The scientific studies referred to in the text can be consulted via the Internet on the Pubmed scientific platform at the following address: https://www.ncbi.nlm.nih.gov/pubmed.